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This family incorporates just one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, moreover histone, various non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear factor kappaB (NFκB), and elements of the TATA binding protein (TBP) complex, TBP-associated components TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, Ok/R-S/T-Okay (target lysine is bold), is also acknowledged by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of those substrates 17 , ninety four Subsequently KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of each histone and non-histone proteins.
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